A single vehicle crash on Highway 401 in Woodstock has left a Windsor resident fighting for their life.

Police say a vehicle was eastbound Tuesday afternoon on the highway when the 66-year-old driver lost control, striking the centre median before crossing all the lanes and crashing into the ditch.

The driver was taken to local hospital with serious life-threatening injuries.

Highway 401 was closed for several hours Tuesday while police investigated.

More information is expected to be released once it is available.