WATCH: Late Night Hosts Address Vegas Attack, Gun Control

Sunday night’s attack on music fans in Las Vegas prompted late night talk show hosts to strike a serious tone on Monday.

Jimmy Kimmel was visibly emotional as he spoke about the tragedy during his monologue.

“Here we are again in the aftermath of another terrible, inexplicable, shocking and painful tragedy — this time in Las Vegas, which happens to be my hometown," said Kimmel.

“We wonder why, even though there's probably no way to ever know why a human being would do something like this to other human beings who were at a concert having fun listening to music.”

MORE: Stars Share Shock, Grief In Wake Of Vegas Attack

Kimmel went on. “Children are without parents and fathers are without sons, mothers without daughters. ... It’s the kind of thing that makes you want to throw up. Or give up. It’s too much to even process.

“I don't know why do our so-called leaders continue to allow this to happen? Or maybe a better question, why do we continue to let them allow it to happen?”

Kimmel called for a real conversation about gun control.

“Common sense says no good will ever come from allowing a person to have weapons that can take down 527 Americans at a concert," the host said. "Common sense says you don’t let those who suffer from mental illness buy guns.”

He urged his audience to put pressure on their elected officials. “It’s not enough to send your love and prayers.”

Conan O’Brien wondered aloud when mass shootings became ubiquitous in American culture.

“When did this become a ritual and what does it say about us that it has?”

O’Brien added: “I'm not the most political of our comics, but I will repeat what I said not long ago after Orlando — I don't think it should be so easy for one demented person to kill so many people so quickly.

“Something needs to change."

On The Late Late Show, UK-born host James Corden spoke about the tragedy.

“Last night was the biggest mass shooting in United States history,” he said. “That’s a record that’s been set twice since the two-and-a-half years that I’ve been living in America.

“I come from a place where we don’t have shootings at this frequency so it’s hard for me to fathom, but it should be hard for everyone to fathom. Gun violence should not be a staple of American life.

“Some say it’s too early to talk about gun control. For those victims last night, it’s far too late.”

Late Night host Seth Meyers offered condolences to the victims’ families and praised first responders and others who helped.

“It always seems like the worst displays of humanity in this country are immediately followed by the best, and then sadly, that is followed by no action at all. And then it repeats itself," said Meyers.

The host challenged American leaders. “Are there no steps we can take as a nation to prevent gun violence? Or is this just how it is, and how it's going to continue to be?

“If you're not willing to do anything, just be honest and tell us. ... If it's going to be thoughts and prayers from here on out, the least you can do is be honest about that.”

Stephen Colbert said on The Late Show said Americans can't accept mass shootings as "the new normal" and targeted U.S. president Donald Trump.

"Doing nothing is cowardice. Doing something will take courage," he said. "This is your chance to prove it. You do not owe the Republicans anything. You know the Republicans tried to stop you from being president. Well screw 'em. You want to make America great again? Do something the last two presidents havent been able to do – pass any kind of common sense gun control legislation.

"By all means offer thoughts and prayers but think about what you need to do and then pray for the courage to do it."

The Daily Show host Trevor Noah, who hails from South Africa, also spoke about gun control.

“What's particularly heartbreaking is other than the lives lost, I feel like people are becoming more accustomed to this type of news,” said Noah. “I almost know how it's going to play out. We're shocked, we're sad, thoughts and prayers — and then almost on cue, people are going to come out saying, ‘whatever you do, when speaking about the shootings, don't talk about guns.’”

Noah had a message for the victims and the people they left behind.

"I can't give you thoughts and prayers,” he said. “I can only say that I'm sorry. I’m sorry we live in a world where people will put a gun before your lives.”