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A man is dead after a house fire in Oakville on Sunday night.

A man is dead, and a woman is in serious condition after they were pulled out of a burning house in Oakville on Sunday night.

Emergency crews were called to Princess Anne Crescent, near Kerr Street and Speers Drive, at around 8:35 p.m. after neighbours saw smoke billowing out a residence.

Speaking to reporters at the scene, Deputy Fire Chief Andy Glynn said firefighters located a working fire on a second-floor bedroom.

Glynn said crews faced heavy smoke and extreme heat as they quickly knocked down the blaze.

Following a search of the residence, two occupants were located and removed from the home. Both victims, a man and a woman, were rushed to a hospital in serious condition.

The male victim later died in hospital, police said. The woman remains in the hospital.

Glynn said did not find anyone else in the residence.

The cause of the fire is unknown.

The Office of the Fire Marshal has been notified and will take over the investigation.