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OPP investigate after a fatal head-on crash near Port Ryerse, Ont. on Monday, Sept. 30, 2019. (Ontario Provincial Police - West Region / Facebook)

LONDON, Ont. - One person has died and three others suffered life-threatening injuries in a "violent" head-on collision west of Port Dover, Ont.

Norfolk County OPP say the crash happened on Highway 6 near Port Ryerse Road around 3:15 Monday afternoon.

Three other people were sent to hospital with serious, life-threatening injuries. Two were airlifted to hospital.

Highway 6 was closed in both directions for several hours as police investigated the crash.

It remains unclear what caused the collision and whether charges will be laid.

- With files from CTV Kitchener's Chase Banger